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Moreover, it has been shown that parasites such as Trypanosoma cruzi (T

doi:10.1080/22221751.2020.1733440

While much of the literature focuses on acute inflammatory mediators such as IL-1, IL-6, and TNF-, chronic COPD is also driven by long-term activation of endogenous danger signals and persistence of tissue DAMPs, which sustain an exaggerated inflammatory environment over time